Paracetamol Dosing Calculator

Evidence-Based Clinical Tool for Dengue Patients

Medical calculator

Evidence-Based Dosing

Based on Pandejpong et al. (2015): Hepatotoxicity risk increases significantly with doses >8g total (OR=4.62). Recommended maximum: <3g/day

Patient Information & Dosing Calculator

Clinical Assessment

Risk Factors

Dosing Recommendations

Enter patient information to get personalized dosing recommendations

Interactive Safety Visualization

Evidence Base:

• Pandejpong et al. (2015): OR=4.62 for hepatotoxicity with >8g total dose

• Vasikasin et al. (2019): Multicentre RCT on paracetamol safety in dengue

• WHO/CDC Guidelines (2024-2025): Conservative dosing recommendations

Safe Dosing Guidelines

  • Adults: Maximum 1g every 8 hours (3g/day)
  • Children: 10-15 mg/kg every 6-8 hours
  • Duration: Limit to fever duration, typically 3-7 days
  • Monitoring: Check liver function if prolonged use

Critical Warnings

  • Contraindicated: Acute liver failure or severe hepatic impairment
  • High Risk: Avoid doses >8g total or >3g/day
  • Drug Interactions: Monitor with warfarin, hepatotoxic drugs
  • Alternative: Avoid aspirin/NSAIDs due to bleeding risk

Emergency Escalation Criteria

Immediate Medical Attention Required:

  • • Severe abdominal pain
  • • Persistent vomiting (≥3 times/24h)
  • • Bleeding (nose, gums, stool)
  • • Difficulty breathing
  • • Cold, clammy skin

Hepatotoxicity Warning Signs:

  • • Jaundice (yellowing of eyes/skin)
  • • Right upper quadrant pain
  • • Nausea with upper abdominal pain
  • • Altered mental status
  • • Dark urine, pale stools